4DMT is a global leader in gene therapy product research & development. 4DMT and our partners are using scientific innovation to unlock the full potential of gene therapy for patients with genetic diseases. Our robust discovery platform, termed Directed Vector Evolution, empowers us to create customized gene delivery vehicles (novel AAV vectors) to deliver genes to any tissue or organ in the body. These customized products allow us to deliver normal genes to tissues with defective genes (as occurs in genetic diseases).

Aether empowers researchers to make history with the first 3D bioprinter truly capable of printing structures with tissue-scale complexity.

Alector,one of QB3@953’s first companies, is moving on to more spacious locations to continue its development of novel immuno-modulating therapeutics for neurodegenerative diseases. After successfully raising over $60M in 2015 alone and developing multiple clinical candidates, Alector will continue its work in two locations south of our fair city.

Amarantus BioScience Holdings, Inc. is a publicly traded biotechnology company focused on developing therapeutic products with the potential for orphan drug designation in the areas of neurology, psychiatry, ophthalmology and regenerative medicine, and diagnostics in neurology.

AOBiome LLC is developing first-in-class topical biologics for the treatment of inflammatory skin conditions. We have developed extensive scientific and manufacturing expertise on the use of beneficial ammonia-oxidizing bacteria (AOB). AOB are naturally occurring bacteria that metabolize the ammonia found in sweat, creating both nitrite and nitric oxide, with both anti-inflammatory and anti-infective properties. The therapeutic potential of nitrite and nitric oxide are widely recognized, although as yet, largely unrealized as delivery, let alone targeted delivery is extremely difficult. The company's proprietary AOB offers the potential of a first-in-class natural delivery system for nitrite and nitric oxide.

Assembly Biosciences is advancing a new class of oral therapeutics for the treatment of hepatitis B (HBV) infection and novel oral biotherapeutics for disorders associated with the microbiome.

Autodesk Life Sciences delivers a single, integrated cloud-enabled software solution that enhances the disjointed and legacy systems used in today’s discovery process. With software that's easy for scientists to use, simple for coders to extend, and built with collaboration at its core, Autodesk Life Sciences is building a cloud platform for the next generation of biological design.

Bell Biosystems, Inc. is a synthetic biology company based in San Francisco, CA. Our vision is to pioneer the use of synthetic organelles to accelerate product development through discovery, innovation and collaboration.

BioA2Z provides a quick, reliable, specific, potent and economic solution for loss of function assays, target validation, functional genomics, drug discovery, and drug development.

Blueprint Genetics is applying a powerful molecular biology approach called next-generation sequencing to analyze patients’ DNA. Changes in DNA sequence can cause errors in proteins and result in severe medical conditions. Genetic disorders include hereditary diseases that are caused by mutations originating in germ cells and presenting in all cells of an individual, and cancers that occur through sequential accumulation of genetic alterations in somatic cells that typically arise over long period of time. Determining the underlying DNA changes creates opportunities to diagnose genetic disorders, estimate prognosis and select preventive treatments. Next-generation sequencing is enabling comprehensive analysis of hundreds of clinically relevant target genes in a time frame that facilitates clinical reactions. Sequencing detects different types of mutations exchanging single nucleotides (point mutations), adding or removing nucleotides (insertions and deletions) or resulting in larger alterations in chromosomal structure. Blueprint Genetics is applying a targeted sequencing approach called oligonucleotide-selective sequencing “OS-Seq™” (Myllykangas et al 2011) that was developed in Stanford University to analyze disease-specific gene panels. With targeted sequencing it is possible to identify all mutations that have been previously linked to specific genetic disorders as well as novel variants in the disease-associated genes.

Cala Health is a medical technology company pioneering a new class of electrical medicine called neuroperipheral therapy. Neuroperipheral therapy has the potential to address chronic disease by externally stimulating peripheral nerves with body-worn electronics. Cala Health is bringing together experts in neuroscience, consumer electronics, and medical devices to develop accessible therapies that treat chronic disease non-invasively.

CAPP Medical, founded in 2013 by Stanford oncologists and industry veterans, has novel technology designed to isolate and quantify small amounts of ctDNA through a simple blood draw, which has the potential to be used for cancer therapy selection and monitoring tumor response and resistance in therapy. Roche Acquired CAPP Medical to Strengthen Cancer Diagnosis in April 2015.

Cell Design Labs, a biotherapeutics company pioneering breakthrough science to develop disruptive cell-based therapies for cancer and other devastating diseases, has been a part of QB3 since March 2016. Based on innovative research from Dr. Wendell Lim's lab at UCSF, Cell Design Labs leverages the power of the body’s immune system to develop smart, living therapies with the potential to treat our most challenging diseases with unprecedented power, precision, safety and durability. While at QB3@953, Cell Design Labs grew from 3 to 20, raised $34M, and established a large partnership with Kite - not bad in a year. Now they have moved on to the East Bay.

CHO Plus is engaged in engineering new generations of mammalian cell lines for the production of Human biopharmaceuticals. Our goal is to provide highly productive GMP-compliant cell lines to satisfy our customers' clinical and commercial manufacturing needs.

CLEO Life Sciences is a unique hybrid model of Chemistry, Manufacturing, and Controls (CMC) consulting combined with a small-scale R&D prototyping lab for pharmaceutical formulation development. We support clients with nimble prototyping of products and processes, using reduced quantities of API and starting formulation development earlier in the drug development cycle. CLEO is able to facilitate rapid efficient tech transfers to GMP contract manufacturing sites, troubleshooting, and scale-up. We enable product & process development on highly accelerated timelines and improve management of CMC technical and execution risks.

COMBiNATi's mission is to support a standard for precision personalized medicine via a widely accessible digital PCR platform.

We are developing a portfolio of novel, non-opioid therapeutics that provide long-lasting pain relief after a single local administration.

Correlia Biosystems is creating proteomic technology that integrates complex assays into rapid, affordable, and portable diagnostic platforms.

Darmiyan's fully automated proprietary software platform inputs human brain MRI and produces maps that detect Alzheimer’s disease up to fifteen years before symptoms. It is impossible to find a cure for Alzheimer’s without early detection, and that's why drug candidates fail one after another. Their mission is to create a fast, non-invasive, inexpensive, precise and globally accessible tool for brain health screening and monitoring. This will help millions of people worldwide who suffer from brain diseases to be diagnosed early and get treated.

Delinia develops novel therapeutics for the treatment of autoimmune diseases. After raising $35M from Sofinova and Atlas, Delinia has moved to the East Bay.

Delpor is a clinical stage life sciences company that utilizes innovative drug delivery technologies to develop new therapeutic products which are based on approved drugs. Our goal is to improve a patient’s quality of life by developing once yearly therapies for chronic conditions.

Enable Biosciences is developing 1000x more sensitive antibody tests for the early detection and treatment of diseases like HIV and type 1 diabetes. Their technology was invented at UC Berkeley and Stanford by Jason Tsai and Peter Robinson in the lab of Carolyn Bertozzi in 2015. Joined by Dr. David Seftel, MD/MBA, Enable's cofounders have participated in UCSF's Lean Launchpad and Startup 101 programs in addition to Stanford's StartX accelerator program. They are the recipients of grants from the NIH, NSF, and Stanford to develop their technology and won the 2016 Harvard Business School New Ventures Competition for Northern California.

Harnessing the regulatory genome to create next-generation molecular therapies.

Excel BioPharm is developing an innovative technology platform that allows reliable and efficient generation of antibodies targeting multi transmembrane proteins such as GPCRs, transporters, and ion channels. The technology will be made available to strategic collaborators and partners developing antibody therapeutics. In the meantime, the Company offers custom antibody services, using both established and novel proprietary approaches, to customers interested in developing high quality antibodies in research, in vitro diagnostics, and therapeutic applications.

Flora Therapeutics, Inc. is developing targeted microbial therapeutics based on comprehensive human microbiome data.

Fustibal is a biotechnology startup focused on fostering affordable healthcare through simpler science. To evolve the medical industry, our team dissects life science big data through scientific investigation, reverse engineering, data mining, and computational modeling. In synergy with our drug targeting platform, we design genomic- and proteomic-driven pharmaceuticals. Our mission is to develop economical and accessible molecular diagnostics and therapeutics.

FutureGen BioMed is a biotechnology company headquartered in San Francisco, California. We offer fully integrated and top quality services including antigen & antibody discovery, production and characterization etc. to both academia and the biopharmaceutical industries. FutureGen guarantees that the services will be conducted efficiently, cost-effectively, well documented, and our clients will be updated with actual experimental progress throughout the course.

We strive to create a world where anyone, anywhere in need of blood or an organ gets the right blood or organ that is safe, accessible and affordable. We will be guided by our Core Values of Respect, Integrity, Teamwork and Achievement. In doing so, we will strive to achieve the highest quality products and solutions, bring forth and pursue innovations that advance patient safety and honor our customers with the highest level of service.

indee was founded on the idea that everyone should be able to access safe, effective and affordable healthcare designed to deliver optimal patient outcomes. We believe our patent pending technology will enable gene therapy for the masses.

Sepsis (a complication of some infections) is associated with half of all in-hospital deaths, and is the single most expensive diagnosis nationally ($24 billion). There is no rapid gold standard diagnostic, so physicians largely guess at presence and severity of infection. Blood cultures, which may take 24-48 hours to return, only turn positive in ~30% of all patients with infections, and so are not effective for ruling out infections. Inflammatix (pronounced in-flah-MATT-iks) has a breakthrough solution: we ‘read’ the immune system to determine the presence, type (bacterial/viral) and severity of infection. The technique works by measuring the expression levels of several host immune genes, and then applying proprietary Inflammatix algorithms to produce clinically actionable results. The Inflammatix gene sets have been extensively validated (24 validation cohorts, >1000 patients) and published in top-tier medical journals.

Leadhexa Biotechnologies, Inc. is a Delaware corporation, whose founders have discovered a unique version of the enzyme Manganese SuperOxide Dismutase (MnSOD) which stunningly has the ability to enter cells and mitochondria. The molecule has demonstrated efficacy in numerous preclinical models including actinic keratosis, tumor suppression, radiation protection, protection of kidney damage due to cyclosporine or contrast dye, liver cirrhosis and liver ischemia-reperfusion injury.

Mattershift designs and manufactures nanotube membranes for biofuels, carbon zero fuels, cell-free biological processes, and precise molecular separations and synthesis. The ultimate goal is to realize the promise of molecular factories that print matter from the air.

MedGenome Inc. is a genomics-based diagnostics and research company delivering the best of health care by decoding genetic information contained in an individual’s genome. We are the first mover and market leader in genomics-based diagnostics and research from India with global offices in California. Our mission is to improve global health by developing deep insights into diseases at the genetic and molecular level. Our research solutions apply cutting-edge genomics technologies, bioinformatics, computing, and big data analytics to the genetically diverse and large South Asian population to understand the genetic basis of cancer, metabolic disorders, eye disorders and other rare diseases. We also address important research questions in hereditary diseases, cardiovascular complications and neurological disorders.

We are radically improving how procedures and diagnostics are being done, with a single, non-invasive, accurate, decentralized and non-expensive microRNA detection platform. Miroculus provides novel solutions for Academic Institutions, Genomic Research Centers, Pharma, Biotech and Diagnostics companies, so they can drastically improve their ability to diagnose, monitor and treat disease.

Mission Bio provides a high throughput single-cell analysis platform to enable novel research tools and healthcare diagnostics in the areas of cancer, immunology, and infectious diseases.

Neopeutics is an early stage drug discovery contract research partner. We offer our clients and partners a robust and cost effective set of tools that can be utilised in a variety of contexts in the drug discovery process.

Nirmidas Biotech, Inc. develops, manufactures, and markets breakthrough biological testing, assay and imaging technologies, based on a novel red to near infrared fluorescence (700-1700 nm) detection and imaging platform. We aim to develop personal and portable diagnostics systems for early disease diagnosis and prognosis monitoring, as well as for population-based screening. We also aim to develop an in vivo imaging systems for research, diagnosis, and therapeutics. Our products lie at the intersection of life science research, in vitro diagnosis, in vivo imaging, and digital healthcare.

Nucleo Life Sciences will be expanding their team to broaden the number of formulation and drug development projects they are tackling. Borne out of Actera, another former QB3@953 company, Nucleo Life Sciences incubated with us for a little over one year before outgrowing our location.

Pionyr (formerly Precision Immune Inc.) is developing cancer immunotherapies that target the tumor microenvironment to enhance the body's antitumor immunity. The company is exploiting novel target discovery and antibody generation platform technologies to create the third generation of immuno-oncology therapeutics after checkpoint inhibitors and CAR-T. The company's approach, Myeloid Tuning™, is designed to enhance the immune system's anti-tumor response by altering the cellular infiltrate of the tumor micro-environment with high specificity.

Prellis Biologics is developing technology to build transplantable human organs and tissues. Our aim is to address the organ shortage and provide human tissues to streamline the development of therapeutics. The first transplantable human tissues Prellis Biologics is working to develop are the insulin secreting units of the pancreas, Islets of Langerhans. A renewable, safe source of Islets of Langerhans will provide an option to millions of people living with Type 1 Diabetes Mellitus (T1DM). An islet transplant may allow T1DM patients to become insulin independent thereby avoiding daily injections and finger pricks for monitoring and regulating dangerous blood sugar swings. In addition, our company has developed a printing process to create human Lymph Node Organoids (LNO), capable of immune responses and generation of human antibodies, bypassing the need for antibody development in animals. In our proof-of-concept studies, our scientists created 14 novel class-switched human IgG antibodies that are reactive to the Zika Virus in less than 6 weeks. By engineering human tissues in the laboratory for rapid therapeutics development, our technology will streamline bench-to-bedside research and efficiently address emerging disease outbreaks. Prellis Biologics was co-founded in 2016 by Dr. Melanie Matheu and Dr. Noelle Mullin, two PhDs with a passion for bringing engineering and biology together to solve unmet medical needs.

Proxeom is focused on improving cancer survival with technologies for highly-sensitive detection of mutations in circulating cell free DNA enabling early detection, monitoring progression or regression of cancer, detecting metastasis and predicting relapse. By sampling blood and body fluids such as urine, semen, uterine exudates, etc. for mutational signatures of cancer; the non-invasive, liquid biopsy based approach can detect the presence of a tumor in the body as well as provide guidance on therapy.

Revitope is developing a novel approach to cancer immunotherapy. Cancer patients typically have strong cytotoxic immunity against viral pathogens while lacking immunity against their tumors. Revitope’s technology redirects an exisiting viral immune response to treat cancer. Revitope’s antibody peptide epitope complex (APEC) technology selectively delivers an immunodominant viral peptide to the tumor cell, thereby activating exisiting T cells that recognize the tumor as virally infected, and kill it. Revitope is backed by a strong team of scientific founders, management team and investors. The company’s goal is to harness its platform to develop multiple therapeutics for the treatment of solid tumors and hematologic malignancies. Revitope is headquartered in San Francisco. Revitope’s founders are based in Boston, at Harvard/Massachusetts General Hospital.

Enzymes are widely used in molecular biology and genomics research. We use protein engineering to improve enzyme properties for better in vitro application.

This pea-based milk is healthier than almond milk. Ripple is a nondairy milk that won’t quite fool you into thinking it comes from cows – but is far better for the planet than the milk that does.

Safe-H2O Inc. is a water bio detection company providing rapid pathogen test systems and data services; assisting water providers and water treatment service providers in reducing fatalities and illness related to waterborne pathogens and assuring sustainability of water systems.

Few people know that in only one out of three cancer patients benefit from first line anti-cancer therapy. This is because every tumor is unique and thus knowing which therapy would work best in an individual patient remains a major challenge for oncologists. SageMedic is working feverishly on a test of the patient’s biopsy to guide oncologists in picking the most effective treatment to double their chance of tumor response, quality of life, and life expectancy.

Every body is unique. No two people are exactly alike. Sano uncovers the unique biometric information that’s vital to understanding your health. Our mobile app provides easy access to your current glucose levels and historical trends to turn insight into action.

SillaJen is a global leader in oncolytic immunotherapeutics targeting, attacking, and eradicating cancers.

SiteOne is a biotech founded by Stanford University researchers to develop safer, more effective, non-narcotic pain medicines for acute and chronic pain management. SiteOne is also advancing novel molecular diagnostics for locating pain generators – information that would more accurately guide the treatment of chronic pain. Our therapeutic and imaging agents target sodium channels in pain-sensing nerves. The therapeutic program applies our proprietary chemistry to target the 1.7 sodium channel subtype and the imaging program is developing novel PET ligands.

Sound Agriculture, formerly known as Asilomar Bio, is developing technologies to help growers sustainably increase productivity by enhancing crop nutrient and water use. The Company is working to launch its first products in collaboration with partners.

Symic Bio is a biopharmaceutical company developing a new category of therapeutics focused on matrix biology. The (extracellular) matrix is the non-cellular component of the body’s tissues and can be envisioned as a sponge-like environment surrounding the cells of a tissue. In this environment, cells proliferate, migrate and differentiate. Research in recent decades has demonstrated the biological importance of the interactive and dynamic relationship between cells and their matrix environment. The Symic Bio platform of matrix-targeting biotherapeutics builds upon this research. These therapeutics, inspired by naturally occurring macromolecules of the matrix called proteoglycans, bind to targets in the matrix damaged in response to injury or because of disease. They are designed to inhibit pathological inflammatory responses and to affect matrix degradation and structure.

Synvitrobio collects rapid biological data through cell-free systems.

TB-SEQ, Inc. is a life sciences company based in San Francisco, CA. TB-SEQ has developed a platform technology based on NGS sequencing for discovering and monitoring expression of proteins and regulatory peptides. TB-SEQ's technology greatly facilitates functional-genomics and protein-biomarker identification analyses in biomedical, pharmaceutical, and agricultural applications.

Tiatros offers safe and affordable evidence-based group psychotherapies inside HIPAA compliant private social networks, where patients learn CBT+ skills and practice them with others who have similar health challenges and goals. Tiatros captures the unstructured data contained in psychiatric evaluations, patient narratives and interactions, preserving their clinical richness. We're working with leading cognitive computing and AI vendors to revolutionize the delivery of psychotherapies.

Trace Genomics is building an artificial intelligence and genomics platform to tackle agricultural diseases. Our genomics-based infectious disease panel digitalizes sample states, delivering actionable information to farmers to enable precision agriculture. Our vision is to build a global database of emerging and significant pathogens and enable data-driven product design for agriculture using machine learning.

ViewPoint Therapeutics is dedicated to the discovery, development, and commercialization of treatments for protein misfiling diseases, including cataracts. Their initial focus is crystallin biology. To address the global need for new methods to treat cataracts and presbyopia, they are pioneering the development of crystallin stabilizers to stabilize the functional form of the crucial human lens protein alpha-crystallin against accumulated damage. By developing VP1-001 as a small molecule medicine suitable for topical application, Viewpoint hopes to revitalize the treatment paradigm for vision loss associated with presbyopia and cataracts.

ViewPoint was founded in July of 2014 based on technology developed in the lab of Jason Gestwicki at the University of Michigan – now professor at UCSF, in collaboration with the lab of Usha Andley at Washington University in St. Louis, and is led by Leah Makley, CEO.

In every one of us there are there are millions more bacterial genes than human ones. This microbiome, comprised of all of the microorganisms inhabiting us, represents a significant opportunity for improving human health. Whole Biome will provide health product, pharmaceutical and research organizations with the CompleteBiome Test(™) that contains clinically-relevant information on this complex ecosystem. This will enable a revolution in personalized medicine where each individual’s treatment will be driven by a comprehensive understanding and a targeted equilibration of their microbiome.

At Zymergen, we engineer biology predictably, reliably and to a level of performance previously unattainable through traditional R&D. We work with Fortune 500 companies that span industries, including chemical and materials, agriculture, and healthcare. Zymergen works with our customers to improve the economics of existing industrial fermentation products. Our platform enables us to build improvements into their existing production strains within their existing manufacturing processes. We augment our customers’ capabilities and help them get more out of their existing capital assets. Zymergen has a track record of improving capital utilization for customers’ existing products, accelerating time-to-market for new products, and delivering significant cost reductions for both.