Scientist, Protein Engineering

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Scientist, Protein Engineering

About Us
Escalante is dedicated to enabling the next generation of biological insights. Our platform unlocks scalable, functional, single-molecule proteomics by combining cutting-edge molecular biology, protein biochemistry, and artificial intelligence. We want to build AI models with a real understanding of how cells work. These models would transform biology and drug discovery, but require fundamentally new measurement technologies and datasets. To build these we rely on our people, our ambition, and our willingness to challenge the way science is done.

The Opportunity
As a protein engineering scientist at Escalante you will work closely with an interdisciplinary group of scientists and engineers to develop the next generation of scalable single-molecule proteomics. This role is a wet-lab based position where you will work with RAs to design and execute high-throughput proteomics assays for machine learning model training, develop robust assays for QC and validation of our platform and work with automation engineers to efficiently scale our process. Through this work you will directly contribute to our core platform and help guide Escalante’s trajectory. This is a full-time on-site role in San Francisco, California.

Responsibilities

• Implement lab methods to prepare large pools of protein binders, and combine biochemical and genomics techniques to optimize and QC these pools
• Mentor a research assistant to execute wet lab assays quickly and rigorously
• Work with ML scientists to design high-throughput, data rich assays for model development
• Advise machine learning team by providing expertise on protein biology

About You

• PhD in a biology related field, with 0-2 years of industry experience
• Expertise in protein biochemistry, protein purification and protein biophysics
• Experience in designing and executing large-scale pooled protein assays. Including the design of plasmid libraries, protein purification, assay development, and analysis.
• Excited to be involved in all aspects of experimental biology with responsibilities ranging from generating data at the bench to writing code and analyzing experimental data
• Strong background in computational biology including familiarity with Unix, Python, Jupyter notebooks and libraries such as Pandas, Numpy etc
• Outstanding ability to record and communicate scientific work

Plus

• Experience with chemical conjugation techniques

Compensation: competitive salary+ equity + benefits.
Benefits Include: Generous paid time off, 100% health coverage, employee stock option plan, paid parental leave, office snacks and beverages

Escalante is committed to equal employment opportunity regardless of race, color, ancestry, national origin, religion, sex, age, sexual orientation, gender identity and expression, marital status, disability, or veteran status. Pursuant to the San Francisco Fair Chance Ordinance, we will consider for employment qualified applicants with arrest and conviction records.

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