Scientist—Immuno-Oncology

http://gpcr.co.kr/career/

Scientist—Immuno-Oncology GPCR THERAPEUTICS, USA
The Company

Join an exciting venture-backed startup in San Carlos, CA with a novel approach for targeting G Protein-Coupled Receptors (GPCRs) based on cutting-edge technology. The company has discovered specific GPCR heteromers that result in enhanced cell signaling and disease progression. Drugs that target disease-specific heteromers in cancer are under development.

Scientist, Immuno-Oncology

GPCR Therapeutics, USA is now building a foundational R&D team and is looking for a highly motivated and independent Scientist to join our immuno-oncology team. In this key role, you will have a significant impact on our portfolio by advancing cancer immunotherapies from discovery to IND-enabling studies. Your activities would include development of immunological assays, screening to identify effective therapeutics, immune cell profiling from mice and human samples, and support for the preparation of patent applications.

Key Responsibilities

Design and execute experiments to drive target validation, target engagement and therapeutic assessment in immune cells using a variety of immune-based assays that include primary immune cells
Lead and execute scientific research of early-stage immune oncology discovery programs and develop strategy in moving those programs through pre-clinical development
Develop innovative in vivo/ex vivo/in vitro assays/analyses to interrogate the function of immune and tumor cell populations and their interaction
Resolve key project hurdles with available information from literature and internal or external experts
Write reports, submit patents, make internal presentations, and publish original discovery in peer-reviewed journals.
Mentor/supervise junior scientists
Maintain compliance with all company policies and procedures.
Personal Qualities:

Demonstrated strong work ethic, curiosity to learn and a self-starter who takes initiative
Excellent communication and organizational skills
Attentive to details and consistent in delivery of high-quality work
Excellent analytical and problem-solving skills
Can streamline workflow and multitask to contribute to a fast-paced collaborative environment
A team player who can collaborate effectively
Highly tolerant and respectful of all members of a small startup company
Ideal Educational Requirements and Experience:

PhD in immunology, molecular biology, cancer biology or related discipline is required with a minimum of 5 years of biopharmaceutical industry experience.
Experience with multiparameter flow cytometry, primary murine and human immune cell assays and immunological read-outs is essential.
Proficiency with FlowJo, GraphPad Prism, Microsoft Word, Excel, and PowerPoint is required.
Strong knowledge of immune cell biology and immunology are required.
Demonstrated track record of independent critical thinking and scientific achievement as exemplified by your publication record and/or significant contributions to a therapeutic development program.
Possess a broad understanding of drug development especially cancer immunotherapy. The ideal candidate will have experience in drug screening and compound prioritization. Experience in assisting in portfolio prioritization is critical.
Very strong bench skill set with experience in basic molecular and cell biology including but not limited to cytokine profiling, immune profiling, surface protein expression, complex immune assays (MLR, CD3/CD28 activation, CMV antigen recall, Treg and MDSC suppression assays, DC polarization and antigen presentation, etc.)
Compensation

We offer a competitive salary, commensurate of a young startup in Silicon Valley, plus generous stock option allocations and benefits.

Corporate Culture at GPCR Therapeutics, USA

We are a small company that fosters a respectful, friendly, informal, and non-hierarchical work environment. We embrace rigorous and meticulous science with a belief in continuous growth and learning. We strive for excellence in performance and quality of work, and at the same time, we believe in maintaining a healthy work/life balance.

If you are interested in this opportunity, I would be happy to set up a time to speak with you. Please send a copy of your resume to:

Nina.Caculitan@gpcr.co.kr