Website GPCR Therapeutics USA
We are an early stage Biotechnology company focusing on GPCRs.
Senior Scientist-Antibody Engineering GPCR THERAPEUTICS, USA
Join an exciting venture-backed startup in San Carlos with a novel approach for targeting GPCRs. Located in San Carlos, CA and in S. Korea, GPCR Therapeutics, Inc. http://gpcr.co.kr, is a venture backed startup company developing pharmaceuticals against G Protein-Coupled Receptors (GPCRs) based on cutting-edge technology. The company has discovered specific GPCR heteromers which, when formed, result in enhanced cell signaling. Drugs that target disease-specific heteromers in cancer are under development.
Senior Scientist, Antibody Engineering Opportunity
GPCR Therapeutics, USA is now building our foundational R&D team, and we have an opening for a Senior Scientist, Antibody Engineering to join the team. This is an opportunity to have a significant impact on our portfolio by helping us build our Biologics group.
Main Roles & Responsibilities
The Senior Scientist, Antibody Engineering will be part of the Therapeutic Antibodies R&D division of GPCR Therapeutics, USA. This employee will be a member of a cross- cross-disciplinary team in support of new applications of GPCR’s technology to antibody characterization for discovery of novel and highly differentiated therapeutics, biomarkers and measurements of response to therapy, adverse event prediction or monitoring.
Work in close collaboration with other members of the team in the characterization of diagnostic and therapeutic antibodies.
Be responsible for antibody discovery using murine immunization and/or phage display technology
Be responsible for antibody expression and re-formatting (including humanization, affinity maturation, isotype switching, bi-specific technologies, detection tags, chemical payloads and Fc engineering)
Support stable and transient expression of antibodies and antigens
Run basic antibody and antigen characterization experiments such as electrophoresis (native and/or SDS-PAGE, western blots) and protein quantification (spectroscopy UV/Vis, fluorescence).
Support analytical and biophysical characterization of antibodies using HPLC (IEX, SEC, affinity etc), antibody-antigen interactions (Biacore, Octet and other biosensor platforms), stability and aggregation (DSC, DLS, etc.), immunoassays (ELISA, Luminex and other platforms)
Support antibody small- and medium-scale purification (AKTA, BioRad, etc equipment)
Interface with collaborators and/or customers on assigned projects
Participate in the preparation of technical reports, summaries, protocols, and presentations
Provide update of project status at periodic project review meetings
The position will report directly to the CSO and requires the ability to work in a team and working largely unsupervised.
Demonstrated strong work ethic, curiosity to learn and contribute in a fast-paced collaborative environment
Excellent communication and organizational skills
Self-starter who can take initiative
Excellent analytical and problem-solving skills
Can streamline workflow and multitask
Ability to work in a collegial manner—a team player
Highly tolerant and respectful of all members of a small startup company
Ideal Educational Requirements and Experience
At least six years of academic/industry experience in protein and antibody engineering with demonstrated hands-on expertise in the field of protein science and immunoassays is preferred
D. degree in Biochemistry, Structural Biology, Biophysics, Molecular Biology or related field
Experience in directing research assistants
Technical Skills & Qualifications
Prior experience with antigen and antibody expression from eukaryotic systems is required, prokaryotic systems a plus
Prior experience in antibody and protein purification and characterization using a variety of analytical and biophysical techniques
Hands-on expertise should include molecular biology and protein biochemistry, screening antibody libraries, ELISA, biosensor, and/or other biochemical and cell-based assays
Skilled in computer applications and proficient in using a variety of computer hardware
We offer a competitive salary, commensurate of a young startup in Silicon Valley, plus generous stock option allocations and benefits.
Corporate Culture at GPCR Therapeutics, USA
We are a small company that fosters a respectful, friendly, informal, and non-hierarchical work environment. We embrace rigorous and meticulous science with a belief in continuous growth and learning. We strive for excellence in performance and quality of work, and at the same time, we believe in maintaining a healthy work/life balance.
Also open at GPCR Therapeutics, USA
Pharmacology (Research Associate)
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