Senior Research Associate
Research · San Carlos, California
About Tranquis Therapeutics:
Tranquis Therapeutics is a clinical-stage biopharmaceutical company based in the San Francisco Bay Area. Tranquis discovers and develops innovative medicines with the potential to revolutionize the management of neurodegenerative and aging-related diseases and to dramatically reduce the burden these illnesses place on patients, families and societies worldwide.
Founded on groundbreaking immuno-neurology research from the laboratory of Edgar Engleman at Stanford University, Tranquis’ novel therapeutic approach targets underlying myeloid immune cell dysfunction that has been linked to a variety of nervous system disorders.
The company’s portfolio is comprised of small molecules that cross the blood-brain barrier, and the lead molecule, TQS-168, has demonstrated beneficial effects in preclinical models of Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia (FTD), Parkinson’s Disease (PD), and age-related cognitive impairment.
The Senior Research Associate or Associate Scientist will conduct and assist in research efforts to develop cell-based assays involving mammalian cells and perform various molecular biology techniques for analysis. Previous experience with and willingness to learn, design and execute assays using human and mouse PBMCs, human IPSC-derived cells and mouse primary cells is required. The candidate will work closely with different members of the Discovery Research team Working in a highly collaborative environment, the Senior Research Associate will contribute individually and make an impact in the overall department’s goals.
Cell cultures of cell lines, primary cells, peripheral blood mononuclear cells (PBMCs), IPSC-derived cells, including media preparation, seeding, monitoring, maintenance, harvest, cryopreservation, and preparation for use in cellular assays
Operate laboratory equipment related to cell culture such as cell counter, microscope, centrifuges and plate reader
Perform and optimize cellular assays measuring cytokine release, gene expression, and metabolic function
Assist in efforts to develop novel cell-based assays for small molecule screening and exploration of mechanisms of action
Perform standard molecular biology techniques including DNA, RNA and protein extraction, RT-qPCR, and Western blot
Perform standard laboratory assays including ELISA and MSD
Follow prescribed laboratory methods and good attention to details
Maintain accurate and detailed records using laboratory management systems
Meet deadlines in support of team and broader company objectives
Regularly discuss data with manager and team members
BS or MS in a biological science (biology, biochemistry, neuroscience, immunology).
Minimum of 3 years of laboratory experience in an industry or academic setting
Strong experience in cell culture and different in vitro assays (colorimetric, fluorometric, bioluminescence etc.)
Experience with methods in molecular biology including nucleic acid extraction and PCR/qPCR
Excellent organizational and record keeping skills: cataloging and storage of samples, and documentation of experiments
Ability to communicate results and conclusions within the biology group and cross functional project teams
At Tranquis Therapeutics we believe a diverse workforce drives our success as a company. We are always working to create an environment where different backgrounds and viewpoints are valued and celebrated.
Tranquis Therapeutics is an equal opportunity employer. Tranquis Therapeutics makes employment decisions, including in recruitment and selection, without consideration of race, color, national origin, religion, sex, gender, gender identity or expression, sexual orientation, age, veteran status or disability.
Tranquis Therapeutics is a mandatory vaccination workplace. Offers of employment are contingent on proof of vaccination against COVID-19 or qualification for exemption for medical reasons or a sincerely held religious belief.
Recruiter Statement: Tranquis Therapeutics acknowledges that providers may be a valuable resource for identifying and recruiting candidates for employment. However, we require that all recruiters engage directly with Tranquis Therapeutics Human Resources Team and comply with Tranquis Therapeutics’ requirements prior to transmitting any resumes/CVs or introducing any candidates to Tranquis Therapeutics. Tranquis Therapeutics’ Human Resource Team is the only function within the Company that can enter contractual relationships with external recruiters and recruiting agencies.
To apply for this job please visit tranquis.bamboohr.com.